The regulation of vasopressin secretion in a patient with oat cell carcinoma of the bronchus.

Copeptin,as a new Boimarker

everything that disturbs the homeostatic balance of the body can be defined as stress and any stress factor activating the hypothalamic- pituitary-adrenal (HPA) axis causes an increase in arginine vasopressin (AVP) plasma concentrations. AVP is a 9 amino acid peptide in the ring structure and derived from pre-pro vasopressin. Pre-pro vasopressin is a pro hormone that synthesized by supraoptic ...

Diabetic ketoalkalosis due to ectopic ACTH production from an oat cell carcinoma.

A diabetic patient is described who presented with the bizarre biochemical association of hyperglycaemia, ketosis and severe alkalosis. Investigation revealed hypercortisolaemia due to ectopic adrenocorticotrophic hormone secretion from an oat cell carcinoma of the bronchus and post-mortem studies demonstrated clinically unsuspected resolving pancreatitis. a possible mechanism for the metabolic...

Oat cell carcinoma of bronchus presenting as an acute psychiatric illness in young women.

Two young women are described who presented with an acute psychiatric illness, due to the metabolic effects of inappropriate anti-diuretic hormone (ADH) secretion. In both patients symptoms were promptly abolished by correction of the biochemical disturbance and subsequent investigations revealed hitherto occult oat cell carcinoma of bronchus. These patients demonstrate the value of routine lab...

Hyponatremia, Antidiuretic Hormone Secretion and Oat Cell Carcinoma of the Lung.

Inappropriate antidiuretic hormone secretion in oat-cell carcinoma of bronchus. Aggravation of hyponatraemia by intravenous cyclophosphamide.

Hyponatraemia associated with bronchial carcinoma was first described by Winkler and Crankshaw (1938). Schwartz, Bennett, Curelop, and Bartter (1957) suggested that the hyponatraemia was due to 'inappropriate' secretion of antidiuretic hormone (ADH) by the tumour itself. Confirmation of this was provided by Lee, Jones, and Barraclough (1964) when a substance with an action resembling that of AD...